Anthem
group companies

Driven by drug discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Terostil

Terostil

Each capsule consists of Pterostilbene 50 mg. Terostil is unique product of Anthem Biopharma. Terostil is extracted from Blueberries.

The centers for Disease Control and Prevention (CDC) recommend that Individuals make healthier lifestyle choices that include not smoking, taking part in daily physical activity and eating a diet that contains a variety of fruits and vegetables (CDC 2011). A diet rich in fruits and vegetables is important for preventing and managing CVD as items in these food groups contains phytochemicals that offer protection against both hyperlipidemia and hypertension. Human, animal and in vitro data linking phytochemicals to CVD are persuasive (NETO 2007).

Of all the fruits and vegetables, blueberries are known to have one of the highest antioxidant capacities. The phytochemicals in blueberries protect the body against the effect of free radicals (NETO 2007). As our bodies break down food, they produce by-products such as free radicals, which can attack healthy cell and may play a role in cardiovascular diseases. Oxidative and the production of free radicals , may be caused during metabolism and by environmental agents, such as tobacco smoke (Sies 1997). Antioxidants remove free radical and prevent these agents from initiating CVD (NETO 2007). Antioxidants are being explored for use in dietary supplements and as additives for the prevention of many diseases, including cardiovascular disease and metabolic syndrome. Among all of the phytochemicals contained in blueberries, pterostilbene has significant cardio-protective potential.


Clinical Trial on pterostilbene


Investigators evaluated the ingredient in 80 patients with high cholesterol (total cholesterol of 200 or greater and/or LDL cholesterol of 100 or greater). Twice daily for six to eight weeks, participants received either high (125 mg) doses of pterostilbene, low (50 mg) doses of pterostilbene, pterostilbene (50 mg) with grape extract (100 mg), or a placebo, said Daniel M. Riche, the study's principal investigator. Investigators assessed patients' blood pressure, body weight and blood lipids at the beginning and end of their participation in the study.

"We found reduced systolic and diastolic blood pressure in patients who received the high dose of pterostilbene and reduced systolic blood pressure in patients who received the low dose of pterostilbene with grape extract," said Riche, an assistant professor of pharmacy practice and medicine at the UM Medical Center in Jackson.

Participants in the high-dose pterostilbene group (250 mg per day) achieved significant reductions in blood pressure compared to placebo: 7.8 mmHg in systolic BP (p less than 0.01) and 7.3 mmHg in diastolic BP (p less than 0.001).

The only change in lipids was an increase in LDL cholesterol with pterostilbene (24.9 mg/dL, p less than 0.001), which was less among participants already on cholesterol-lowering medication and was not seen among those who also received the grape extract. Participants not on cholesterol medication also achieved a minor average reduction in body weight (reduced body mass index of 0.59 kg/m2) with pterostilbene; body weight did not change significantly compared to placebo for the other participants.

"We saw reduced overall blood pressure in patients who received the high dose of pterostilbene," said the study's principal investigator, Daniel M. Riche, PharmD, Cardiometabolic Clinic Coordinator at the University of Mississippi School of Pharmacy. "The results of this study highlight that pterostilbene is a promising ingredient in the area of cardiometabolics."

Pterostilbene is believed by many experts to show great promise for supporting heart health, cognitive function, anti-aging, weight loss and other metabolic disorders. Pterostilbene has superior biological activity, better oral bioavailability and metabolizes more slowly in the body than other antioxidant polyphenols (substances from plants that tend to prevent or neutralize the damaging effects of free radicals), resulting in more prolonged antioxidant activity.

The study, a double-blind, placebo-controlled trial, included 80 adults averaging 54 years of age with high cholesterol (total cholesterol of 200 or greater and/or LDL cholesterol of 100 or greater). Most participants were women (71%) and some had been diagnosed with high blood pressure (55%). The mean average baseline systolic blood pressure (BP) was 127.4 mmHg and the mean average baseline diastolic BP was 79.3 mmHg. The American Heart Association guidelines state that >119 mmHg systolic BP and >79 mmHg diastolic BP are classified as pre-hypertensive.[23] Twice daily, participants received high (125 mg) doses of pterostilbene, low (50 mg) doses of pterostilbene, pterostilbene (50 mg) with grape extract (100 mg), or placebo. The investigators assessed participants' blood pressure, body weight and blood lipids at the beginning and end of the study.

By the end of the study, participants in the high-dose pterostilbene group (250 mg/day) achieved significant reductions in BP compared to placebo: 7.8 mmHg in systolic BP (p < 0.01) and 7.3 mmHg in diastolic BP (p < 0.001), without serious adverse events.

Source - ClinicalTrial.gov

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