Anthem
group companies

Driven by drug discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Anthem
group companies

Driven by Drug Discovery
          moving towards affordable biotechnology

Overview

Nephrology is a super specialty division of medicine, which deals with the study of adult and pediatric normal kidney functions, kidney disorders/diseases, treatment for kidney problems and Renal Replacement Therapy (Dialysis and Transplantation).

Nephrology also concerns with systemic conditions that affect the kidneys (such as diabetes and autoimmune disease) and systemic problems that occur as a result of kidney problems (such as renal osteodystrophy and hypertension).


Kidney (Renal) Problems Management


Anthem BioPharma is playing an important role in the management of common clinical conditions involving the kidney such as acute kidney injury, nephritic and nephrotic syndromes, urinary tract infection and chronic kidney disease.

Anthem BioPharma manufactures and markets its brands, Keygraf® (Tacrolimus), Keycept® (Mycophenolate mofetil) and Keycept S® (Mycophenolate sodium) which are prescribed for management of Nephrotic syndrome, IgA Nephropathy and Systemic Lupus Erethematosus.

Anthem BioPharma additionally markets antibiotics brands, such as Peperact® (Piperacillin + Tazobactam), Anthonem® (Meropenem) and Pencilum® (Imipenem + Cilastatin) which are prescribed for the management of Urinary tract infections, sepsis and other life threatening infections.


Chronic kidney disease (CKD)


Chronic kidney disease is also known as chronic renal disease (CRD). CKD is a progressive loss in renal function over a period of months or years. The symptoms of worsening kidney function are non-specific, and might include feeling generally unwell and experiencing a reduced appetite.


Stages of CKD


CKD Stage eGFR level (mL/min/1.73 m2)
Stage 1 > 90 ml/min/m2
Stage 2 60 - 89 ml/min/m2
Stage 3 30 - 59 ml/min/m2
Stage 4 15 - 29 ml/min/m2
Stage 5 (ESRD) < 15 ml/min/m2


Anthem BioPharma has a wide range of products which are commonly prescribed in CKD management. Velvetrol® (Calcitriol) is the hormonally active form of vitamin D which maintains serum calcium levels and regulates parathyroid hormone (PTH). Velvetrol® is widely used by nephorlogist in dialysis and non-dialysis CKD patients.

Nabico3® (Sodium bicarbonate) is prescribed for the management of metabolic acidosis (a common problem occuring in CKD).

Ketohunt™ (Alpha ketoanalogue) is a combination of essential amino acids and keto derivative of essential amino acids. Ketohunt™ supplementation slows down the progression and delays the initiation of dialysis.


Renal Anemia (CKD anemia) & Management


Anemia is an absolute reduction of total number of circulating red blood cells (RBC’s) or reduced hemoglobin level in the blood.

Renal anemia is often associated with renal disease. It is quite common and develops in the early stage of CKD due to lack/absence of erythropoietin (EPO) production from the kidneys.

Anthem BioPharma offers EPOtrend®, an effective recombinant human erythropoietin alfa (rHuEPO) for the management of renal anemia. EPOtrend® is available in the form of vials as well as pre-filled syringes (PFS) with a wide range of dosage strengths. EPOtrend® is manufactured by a recognised leader in Biotech products.

Anthem also offers Kokino™ (Iron sucrose), a safe and effective i.v iron supplement used as adjuvant therapy in the management of renal anemia along with EPOtrend®.


Dialysis

Dialysis is the process for removing waste and excess water from the blood.

It is used primarily to provide an artificial replacement for lost kidney function in people with renal failure / ESRD.

Anthems Brand Thinaclot® (Heparin sodium), is an anticoagulant, derived from porcine mucosa and very effective in preventing blood clotting during dialysis process.


Renal (Kidney) Transplantation


Kidney transplantation is a surgical procedure to remove a healthy, functioning kidney from a living or brain-dead donor and implanting it into a patient with nonfunctioning kidneys. Its purpose is to replace the function of normal kidneys in the condition of end-stage renal disease (ESRD).

Donor kidneys are obtained either from living relatives or from brain-dead organ donors( deceased donor).

After renal transplantation, recipients need to be on immunosuppressive drugs to prevent the acute/chronic graft (transplanted kidney) rejections.

Anthem BioPharma manufacture and markets a basket of immunosuppressive drugs used in transplantation, these include Keygraf® (Tacrolimus), Keycept® (Mycophenolate mofetil), Keycept S® (Mycophenolate sodium) and SIROtrend™ (Sirolimus).

More than a few thousands of denovo renal transplant patients are doing well with Keygraf® and Keycept®/ Keycept S®.

Anthem also manufactures CMVIgone® (Valganciclovir) from its base salt. CMVIgone® is an antiviral agent prescribed in both prophylaxis and treatment of cytomegalovirus (CMV) infection, a common viral infection that occurs after solid organ transplantation.

CMVIgone® is very effective and safe in CMV prophylaxis and treatment.


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